The historic property, at 390 West End Ave., has been home to stars like Al Pacino and Nora Ephron.
The Wainsteins paid $217,998 for the penthouse in 2011. The one-bedroom unit comes with hardwood floors, arched windows and high ceilings.
The listing brokers were Nest Seekers International’s Danny Nassi, Charlett Stevenson and Ryan Serhant, and Brown Harris Stevens’ Lisa Lippman and Jean Adams.
This sale comes as part of Wainstein’s bitter divorce — widely viewed as the nastiest breakup in Housewives history — from estranged husband Michael.
Last year, a New York City judge ruled that Jules could sell the apartment after Michael failed to pay, among other things, child support for their two children.
The buyer of the penthouse is listed in city records as Katherine Kong.